Figure 2. The proposed mechanism of CBD’s effects on psychotic disorder . CBD inhibits FAAH, which results in increased anandamide levels. Anandamide activates CB1, CB2, and TRPV1 receptors. CBD can activate TRPV1 receptors directly. Partial agonism at D2 dopamine receptors might account for the effects of CBD on emotional memory processing by the ventral hippocampus.
AEA, anandamide; 5-HT1A, 5-hydroxytryptamine 1A receptor; TRPV1, transient receptor potential vanilloid 1; D2, dopamine receptor 2; CB1, cannabinoid receptor1; FAAH, fatty acid amide hydrolase.