Figure 2. The proposed mechanism of CBD’s effects on
psychotic disorder . CBD inhibits FAAH, which results in increased
anandamide levels. Anandamide activates CB1, CB2, and TRPV1 receptors.
CBD can activate TRPV1 receptors directly. Partial agonism at D2
dopamine receptors might account for the effects of CBD on emotional
memory processing by the ventral hippocampus.
AEA, anandamide; 5-HT1A, 5-hydroxytryptamine 1A
receptor; TRPV1, transient receptor potential vanilloid 1; D2, dopamine
receptor 2; CB1, cannabinoid receptor1; FAAH, fatty acid amide
hydrolase.