Figure 3. The pathway of CBDs’ antitumor effects. The figure depicts the main signaling cascades elicited downstream of CB receptor activation by endocannabinoids and cannabinoids, which affect all the hallmarks of cancer: inhibition of cell proliferation; cell-cycle arrest; induction of cell death (apoptosis and autophagy); prevention of tumor progression (cancer cell vascular adhesiveness, invasiveness, and metastasis formation); inhibition of angiogenesis in tumor environment; and inhibition of the epithelial–mesenchymal transition.