Study design
Between 01.06.2020 and 01.06.2021 , this retrospective cohort was conducted in the internal medicine departments of two institutions. Before the trial, the local institutional review board gave their approval. Patients or their immediate family signed a written informed consent form. Data were gathered from the hospital databases that include the medical records of a total of 1700 adult patients Our series consisted of 1700 COVID-19 patients (836 females, 49.2%; 864 males, 50.8%) with an average age of 48.23 ± 16.68 (range: 18-93). Clinical were gathered directly from the institutional computerized patient database, including baseline descriptives, prior medical records, date of admission, the treatment process, and results of biochemical and hematological tests.
Patients under the age of eighteen and the presence of comorbidities that could compromise immune functions, such as recent chemotherapy, hematological malignancies, and autoimmune illness, were excluded from the study.