Limitation:
This study focused on the psychological impact of COVID-19 and its related quarantine on medical students in Syria. The sample size in this study was small compared with other population-based cross-sectional studies due to the restriction of the population. Depending on online forms would exclude individuals with limited access to the internet. However, online questionnaires proved to be an effective method to reach a large population in many studies in Syria (14, 18, 19). In addition, the effect of quarantine on mental health could not be isolated from the impact of the war and other social and economic factors. Responses were based on self-reporting tools that might be influenced by subjects’ misconception of their own condition. Socio-economic status (SES) could not be assessed as it is hard to standardize salaries and there are no valid methods to determine SES in Syria, specially that it is inappropriate to ask directly about the salary (18). Also, we could not conclude a causal association depending on the results of a cross-sectional study design. Future large prospective studies using objective assessment methods would provide more conclusive results.