Abstract:
Objective: To study the risk factors of cervical insufficiency
(CI).
Design: Retrospective controlled study.
Setting: First Hospital of Shanxi Medical University.
Population: 209 CI patients with a singleton pregnancy (CI
group) and 348 patients randomly selected (control group).
Methods and main outcome measures: All patients were required
to have records of the whole pregnancy. The general conditions and
pregnancy complications of the two groups were collected. A model of
logistic regression and ROC curves were used.
Results: Patients with a history of multiple pregnancies had a
17.51 times higher risk of CI than negative patients(OR=17.51, 95%CI:
2.16-141.85, P=0.007); patients who were pregnant by IVF-ET/ovulation
induction had a 3.26 times higher risk of CI than negative
patients(OR=3.26, 95%CI: 1.69-6.30, P<0.001); patients with
gestational diabetes (GDM) or pregnancy with diabetes (PGDM) had a 2.88
times higher risk of CI than negative patients(OR=2.88,
95%CI:1.87-4.44, P<0.001); patients with PCOS had an 8.72
times higher risk of CI than negative patients (OR=8.72, 95%CI: 2.33-
32.64, P=0.001); and patients with uterine malformations had a 4.00
times higher risk of CI than negative patients(OR=4.00,
95%CI:1.07-14.97, P=0.040) . The ROC curve showed the combination of
multiple indicators have a certain predictive ability for CI
(AUC=0.728).
Conclusions: Previous multiple pregnancy, IVF-ET/ovulation
induction conception, diabetes mellitus (GDM or PGDM), uterine
malformations, and PCOS are risk factors for the incidence of CI, and
the combination of multiple indicators has some predictive ability for
CI.
Funding: None