Figure titles and legends
Figure 1. Casadevall and Pirofski’s damage-response framework of
microbial pathogenesis. The y -axis denotes host damage as a
function of the host response. Damage can occur throughout the host
response, which is represented by a continuum from ‘weak’ to ‘strong’.
Therapeutic intervention can shift the curve towards benefiting the
host, as denoted by the arrow.
Figure 2. Pharmacological profile of azithromycin during
COVID-19 pneumonia pathogenesis. Establishment of pan-pathogen
antimicrobials facilitates discovery of conserved pharmacological
properties against multiple pathogen types. For example,
lysosomotropicity has emerged as a desideratum for both antimalarial and
antiviral therapeutics. Drug-disease interactions of pan-pathogen
antimicrobials can further provide mechanistic insights into the general
nature of infection. In so doing, pan-pathogen antimicrobials can drive
the unification of the microbiological and immunological disciplines,
first envisioned by Casadevall and Pirofski.