0 |
No evidence; includes in silico predictions without
confirmation |
1 |
In vitro studies with limited value for predicting in
vivo/human situation |
2 |
Animal studies with hypothetical relevance in humans |
3 |
Incomplete studies in humans at the appropriate dose e.g. proof of
concept; few cases from medical records; some clinical effects
observed |
4 |
Well-documented clinical end points observed for repositioned drug
at doses within safety limits |