Methods and results
We retrospectively enrolled 1768 AF patients in our study. Demographic
characteristics, laboratory data and echocardiography were measured and
collected on admission. The primary endpoints were death from all causes
and death from cardiovascular diseases. The secondary endpoints were
major bleeding and stroke. During a mean follow-up of 22.35 months, 155
patients occurred death from all causes. For further analysis, patients
were categorized into two groups according to the optimal cutoff value
of SII level determined by using receiver operating characteristics
curve analysis (low SII group <451.01 or high SII group
≥451.01). The incidence of death from all causes and death from
cardiovascular diseases in high SII group is significantly higher
compared with that in low SII group, (14.3% vs. 5.3%,p <0.001; 9.3% vs. 3.8%, p <0.001,
respectively). However, no significant differences were detected between
two groups for the secondary endpoints (p >0.05). On
multivariable Cox analysis with adjustment of potential confounders, the
risk of death from all causes and death from cardiovascular diseases
increased by 77.6% (hazard risk [HR]=1.776, 95% confidence
interval [CI]: 1.109-3.065, p = 0.018) and 51.2% (HR=1.512,
95%CI: 1.011-3.742, p = 0.025), respectively, in high SII group.