Study selection
Search strategy yielded 514 potentially relevant records. After
screening of titles and abstracts and evaluation of completed trials
retrieved from ClinicalTrials.gov, seven full-text articles were
assessed for eligibility and four [15-18] blinded,
placebo-controlled RCTs were included in the meta-analysis. A flow
diagram of the study selection process and specific reasons for
exclusion are detailed in the Supplement (eFigure 1).