Ethical Approval: All experiments followed the guidelines for
the Care and Use of Laboratory Animals 8th Edition (2011), that is
adopted by the Institutional Animal Care and Use Committee (IACUC) of
Cairo University, Approval number: (CU, III, F, 81, 18).Consent to Participate: Not applicableConsent to Publish: Not applicableAvailability of data and materials: available upon requestCode availability: not applicableAuthor contributions: OAN, MIA, NEE and WMH have made
substantial contributions to conception and design. OAN has made
substantial contributions to conduction of the research, acquisition of
data, their analysis, their interpretation and wrote the manuscript. All
authors have given final approval of the version to be published. The
authors declare that all data were generated in-house and that no paper
mill was used.Funding: This study was financially supported by the Department
of medical pharmacology, Cairo University, Egypt. The authors declare
that the research was conducted in the absence of any commercial or
financial relationships that could be construed as a potential conflict
of interest.Acknowledgements The authors wish to thank Dr Laila Rashed, Professor of Biochemistery,
Faculty of Medicine, Cairo University, Egypt, for the biochemical
results in this study.7. References