3.3 Histopathological analysis
Intra-rectal injection of A-A induced a significant colonic inflammation characterized by architectural distortion, inflammatory infiltration by (neutrophils, eosinophils, lymphocytes and plasma cell), cryptitis and mucosal ulceration in comparison to the control group (P value 0.04) as shown in figure 2 . However, there were no statistically significant differences for overall colonic inflammation between the diseased groups.