INTRODUCTION
Abortion is the spontaneous loss of an intrauterine pregnancy that is clinically determined before the fetus has reached viability.1Chromosomal abnormality is the most common cause of early pregnancy abortion. About 50% of abortions are related to chromosomal abnormality, which is mainly related to abnormal number.2 Recurrence of abortion has a variety of epidemiological factors, including parental or embryonic chromosomal abnormalities, infections, immune factors, hereditary thrombosis, uterine abnormalities, endocrine disorders, nutritional and environmental factors. The detection rate of chromosome abnormality in convection products by karyotype analysis was 50%, and the detection rate of pathogenicity copy number variation by chromosome microarray analysis was about 4%. 3But the cause of the miscarriage is still unknown in 40 to 50 percent of cases. Whole exome sequencing (WES) is a genomic analysis technique that utilizes sequence capture technology to capture and enrich DNA in exon regions of the whole genome for high-throughput sequencing.4According to previous studies, total exon sequencing is used to find the etiology of single gene diseases in flow products, and the diagnostic rate can reach 22%-36%.5Trio -WES was used to analyze the tissue of 14 aborted patients.