Statistical analysis
The data and statistical analysis comply with the recommendations on experimental design and analysis in pharmacology (Curtis et al., 2018). Experimental group size of n = 5 was predetermined based on prior experience in evaluating for statistical significance. One-way ANOVA followed by Bonferroni post hoc test for comparison of multiple independent groups were used for all statistical analyses with the GraphPad Prism version 8.0 for Windows. Statistical analysis was undertaken only when group size was at least n = 5, where nrepresents the number of independent in vitro experiments, not technical replicates. The post hoc test was run only if F value achieved P < 0.05 and there was no significant variance in homogeneity. A P value less than 0.05 was considered as statistically significant.