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\begin{document}

\title{Analgesic Effectiveness between Preemptive Intravenous Acetaminophen and
Single-Shot Caudal Block in Paediatric Inguinal Hernia Repair}



\author[1]{Siti Sarah Othman}%
\author[1]{Huda Zainal Abidin}%
\author[1]{Mohd Zulfakar Mazlan}%
\author[1]{Laila Abdul Mukmin}%
\author[1]{Mohd Shahrulsalam Mohd Shah}%
\author[1]{Nik Abdullah Nik Mohamed}%
\author[1]{Mahamarowi Omar}%
\affil[1]{Universiti Sains Malaysia - Kampus Kesihatan}%


\vspace{-1em}



  
  \date{May 21, 2024}


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\begin{abstract}
In an era where fast-track surgery is preferred and more cases are
performed under day care surgery, anaesthesia techniques and pain
management evolve to suit the demand.In our study, we compared the anal-
gesic effectiveness between preemptive intravenous acetaminophen and
single-shot caudal block in paediatric patients undergoing inguinal
hernia repair.This is a prospective randomised study involving a total
of 40 American Society of Anesthesiologists (ASA) 1 and 2 patients who
are 6 months to 5 years old, randomised into two groups: group A
(intravenous aceta- minophen) and group B (single-shot caudal). Our
primary outcome is the postoperative pain score using Face, Legs,
Activity, Cry, and Consolability (FLACC) scale at several intervals (10
min, 30 min, 1 h, 2 h, and 6 h). The time of first rescue analgesic
requirement was compared. The pain score of group B patients was lower
during the first 1 h postoperatively (p = 0.018) at 10 min, (p = 0.013)
30 min, and (p = 0.05) 1 h and was found to be insignificant beyond the
period. Nonetheless, the mean pain score in both groups was low with
0.15; lowest and 0.45; highest. We found no significant mean time
difference for the first analgesic requirement and mean total opioid
consumption between the two groups. Preemptive IV acetaminophen is
equivocal to caudal block for a paediatric herniotomy surgery. In fact,
IV acetaminophen could give more pharmacoeconomics advantages as it is
easily administered, less time needed hence more rapid turnovers between
the cases and high safety profile%
\end{abstract}%



\sloppy


Title: Analgesic Effectiveness between Preemptive Intravenous
Acetaminophen and Single-Shot Caudal Block in Paediatric Inguinal Hernia
Repair

Authors:

Othman Siti Sarah Mmed(Anaesthesiology) (1), Zainal Abidin Huda
Mmed(Anaesthesiology) (1), Mazlan Mohd Zulfakar
Mmed(Anaesthesiology)(1), Abdul Mukmin Laila Mmed(Anaesthesiology)(1),
Mohd Shah Mohd Shahrulsalam Mmed(Pead Surgery)(2), Nik Mohamad Nik
Abdullah Mmed(Anaesthesiology)(1), Omar Mahamarowi
Mmed(Anaesthesiology)(1)

1) Department of Anaesthesiology \& Intensive Care, School of Medical
Sciences, Hospital Universiti Sains Malaysia,16150 Kubang Kerian
Kelantan, Malaysia.

2) Department of Surgery, School of Medical Sciences, Hospital
Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan,

All authors declare no conflict of interest

Funding from Universiti Sains Malaysia

Address correspondence to:

Zainal Abidin, Huda;

Department of Anaesthesiology \& Intensive Care,

Hospital Universiti Sains Malaysia,

16150 Kubang Kerian Kelantan, Malaysia.

hudaz82@gmail.com

+60199398443

What is already know:

-Paediatric Inguinal hernia repair is one of the most common surgery
done in paediatric populations.

-Caudal block with amide local anaesthetic provides excellent pain
relief for paediatric inguinal hernia repair.

-Intravenous acetaminophen has a high safety profile and used widely in
paediatric patients.

What this study adds:

-Intravenous acetaminophen is equivocal to caudal block in paediatric
inguinal hernia repair surgery.

We found no significant mean time difference for the first analgesic
requirement and mean total opioid consumption between intravenous
acetaminophen and caudal block

\textbf{Hosted file}

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\end{document}

