Quality of evidence
This systematic review is hindered by the poor quality of the papers;
with a lack of randomisation, poor reporting of results, and inadequate
outcome measurements resulting in all studies having “some concerns”
or “high” risk of bias. The heterogeneity in study design and low
number of studies in each comparison arm prevented any meaningful
meta-analysis from being performed. This regrettably means our
conclusion that tissue adhesives, sutures, and staples have equivalent
cosmetic outcomes should be read with caution.