SUMMARY:
What is already known:
Post-traumatic epilepsy is the most provoking consequence after head
trauma with no specific treatment measure.
Epileptogenesis is key term sequelae of altered brain pathophysiology
after brain injury for futuristic PTE.
What this study adds
Potential novel targets have been selected for protecting external
cytoskeleton and internal cytoplasmic infrastructure.
These proposed targets were tried to perform normal functions with
specific potential drug regimens after TBI.
Clinical significance
Fasudil hydrochloride and Flufenamic acid have a significant role to
minimize cerebral edema and inflammation.
The combination groups with Valproic acid have been found more
effective to minimize epileptogenesis in futuristic PTE.