INTRODUCTION
In December 2019, a new strain of coronavirus was identified and
officially named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) [1]. Clinical presentations of coronavirus disease 2019
(Covid-19) can range asymptomatic infection, self-limited influenza like
symptoms, and acute pneumonia to severe respiratory failure. Besides
lungs, kidney involvement is also well defined [2].
Kidney involvement, defined both as urinary abnormalities and changes in
kidney function, has been described among patients with Covid-19 and it
might be present in up to 75% of cases [3].Because of the
expression of the membrane-bound peptidase angiotensin-converting enzyme
2 (ACE2) in tubular epithelia and podocytes and the known property of
ACE2 as a facilitator of cell entry for SARS-CoV-2, it has been proposed
that direct viral infection into the kidneys may account for some of the
acute kidney injury (AKI) pathogenesis for patients with Covid-19
[4]. However, kidney involvement during Covid-19 disease may have a
broad clinical spectrum, and mild kidney injury can easily go
unnoticed.Several studies have found a significant association between
AKI and death among Covid-19 infected patients Early detection of AKI
would be beneficial to identify the patients to improve the clinical
status of Covid-19 patients [4,5].
Urine analysis may be useful to predict the development of AKI and
mortality in Covid-19 patients.Multiple observational studies have
reported the presence of proteinuria and hematuria in Covid-19 patients
[6-12]. However to date, there have been relatively few studies
focussed on urinalysis parameters except hematuria and proteinuria in
Covid-19 patients [6,9,11].
In this study, we aimed to investigate the urinalysisdataof Covid-19
patients on admission and to explore the value of urinalysis in the
prediction of AKI and in-hospital mortality in patients with Covid-19.