FUTURE OF LYCOPENE
It appears that there is no substantial evidence to support or refute the argument that lycopene is successful in the prevention and treatment of prostate disease, based on evidence from clinical and laboratory research (be it BPH or prostate cancer). In a pooled study of observational trials, a high intake of lycopene was linked to a substantial reduction in prostate cancer incidence. While it has been proposed that a daily intake of 6 mg is adequate to maintain lycopene’s antioxidant properties, the optimal daily intake remains uncertain.. The most frequent dosage of lycopene used in recorded RCTs was 15 to 30 mg, but this higher dose was not linked to a reduction in the occurrence of BPH or prostate cancer. However, since the meta-analysis is focused on only two articles, the evidence base on this topic is small.Furthermore, RCT follow-up times have been brief in the past, spanning from four weeks to two years. Conversely, retrospective data suggests a slight but substantial reduction in the prevalence of prostate cancer in men who consume a large amount of lycopene..In case–control and cohort research, though, drawing such optimistic inferences from qualitative evidence should be done with caution due to the possibility of memory and reaction bias, as well as conflicting results. In the United States, it is projected that more than half of customers take dietary supplements on a daily basis, with this number increasing to more than 70% for those over the age of 70. Supplementing with lycopene does not seem to cause damage, but it does have certain benefits. And it may be claimed that the latent harm is the expense of purchasing a therapy that has not been shown to be beneficial, given the vast number of people who purchase those supplements. The methodological consistency and dosage of studies that looked at the benefits of lycopene for the prevention and treatment of prostate cancer differed. Given the scarcity of clinical data, a well-designed RCT with long-term participant follow-up is urgently needed to assess the effectiveness of lycopene in the prevention and treatment of prostate disease.
Several studies have looked into the anti-cancer effect, non-toxicity, efficacy, and preventive or therapeutic functions of lycopene. We gathered data on lycopene’s anti-cancer, anti-progressive, and apoptotic effects on prostate cancer in the current review. Clinical trials show that this adjunctive dietary can be used indefinitely to treat various types of cancers, including prostate cancer in men. In both in-vivo and in-vitro studies, lycopene was found to effectively inhibit prostate cancer cell progression and proliferation, arrest in-cell cycle, and trigger apoptosis.. Lycopene has also been shown to be able to modulate signalling channels and their proteins in the treatment and prevention of prostate cancer.[23]Tomato extracts are linked to a lower risk of prostate cancer when consumed often..[24] Tomatoes are thought to play a minor role in the treatment of prostate cancer. To decide the form and quantity of tomato products that have the potential to prevent prostate cancer, further research is required..[25]