Characteristics of HLA-tested patients and allele frequency
The clinical characteristics of 11,988 patients with HLA testing are summarized in Table II . Overall, 36.7% patients were female. The indications for HLA genotyping were as follows: 39.7% for kidney transplantation, 15.8% for bone marrow transplantation, 9.2% for liver transplantation, 1.8% for donors, 1.2% for lung transplantation, 0.4% for multiple organ transplantation, 0.3% for heart transplantation, and 0.7% for other transplantations.
There were changes to the HLA testing methods over the 10-year study duration, and different testing methods were used depending on the transplanted organ. In total, 11,929 (99.5%) patients underwent HLA-B typing, whereas HLA-DQB1 typing was performed least with the frequency of 20.5% (Table II ).