AbstractIntroduction: Systemic lupus erythematosus (SLE) is a chronic
autoimmune rheumatic disease thatis caused by autoantibodies and immune
complexes forwithunknown reasons and causes damage to cells and organs.
The aim of this study was to evaluate the association of
ANAProfilingpanel antibody with clinical manifestations in patients with
systemic lupus erythematosus.Methods: This retrospective cross-sectional study was performed
on 110 patients (14 males and 96 females) with SLE. Clinical
manifestations were assessed according to ACR and SLICC criteria. In
serum, the surface of ANA Profilling antibodies was examined by
immunoblotting. Results: There was no significant relationship
(chi-square test and Fisher’s exact test) between ANA profiling tests
and disease manifestations including maral rash, discoid, oral ulcer,
nephritis and arthritis. Except for the Anti-Ds DNA test, which was
significantly associated with the clinical manifestations of Maral Rush
and Oral Ulcer. (P-Value <0.05). The results of logistic
regression model show that none of these variables age, sex, malar rash,
discoid, oral ulcer, nephritis and arthritis have a significant effect
on the result Anti -U1RNP / Sm (RNP / Sm),RO-52 recombinant, Anti -La /
SS , Anti-SM, do not have (P> 0.05). Only the age of onset
of the disease has a significant effect on Anti SSA-Ro 60 (60kDa) (SSA)
and Anti-Ds DNA tests on average, the chance of a positive test result
increases by about 25% (P = 0.020 *, OR = 1.246, CI: 1.036-1.499) and
increases by about 16% (P = 0.015 *, OR = 1.165, CI: 1.030-1.317) for
both tests. There was no significant relationship between age of onset
and other test results.Conclusion: The present study shows an increase in the age of
onset of the disease and also a decrease in the percentage of renal
disorders compared to the study of the previous two decades in Iran.
Also, the significant relationship between Maral Rush and Oral Ulcer
with Anti-Ds DNA’s affinity is a confirmation of the results of
extensive studies on this’s affinity, which is also confirmed by the ACR
criterion.