Comparison between the relationship between serum levels of ANA Profiling panel antibodies and clinical symptoms in patients with systemic lupus erythematosus
Shokrihasan1 Rafatpanahhoushang 2Hashemzadehkamelia3
  1. Drpt. Of genetics , facuhty of scinence isalamic azad univercity mashhad iran . (hasanshokri1359@yahoo.com)
  2. Mashhad University of Medical Sciences, Inflammation and inflammatory Diseases Research Centre.(rafatpanahh@mums.ac.ir)
  3. Mashhad University of Medical Sciences EmamReza Hospital, Associate of Rheumatology, Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Iran.(hashemzadehk@mums.ac.ir)
AbstractIntroduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune rheumatic disease thatis caused by autoantibodies and immune complexes forwithunknown reasons and causes damage to cells and organs. The aim of this study was to evaluate the association of ANAProfilingpanel antibody with clinical manifestations in patients with systemic lupus erythematosus.Methods: This retrospective cross-sectional study was performed on 110 patients (14 males and 96 females) with SLE. Clinical manifestations were assessed according to ACR and SLICC criteria. In serum, the surface of ANA Profilling antibodies was examined by immunoblotting. Results: There was no significant relationship (chi-square test and Fisher’s exact test) between ANA profiling tests and disease manifestations including maral rash, discoid, oral ulcer, nephritis and arthritis. Except for the Anti-Ds DNA test, which was significantly associated with the clinical manifestations of Maral Rush and Oral Ulcer. (P-Value <0.05). The results of logistic regression model show that none of these variables age, sex, malar rash, discoid, oral ulcer, nephritis and arthritis have a significant effect on the result Anti -U1RNP / Sm (RNP / Sm),RO-52 recombinant, Anti -La / SS , Anti-SM, do not have (P> 0.05). Only the age of onset of the disease has a significant effect on Anti SSA-Ro 60 (60kDa) (SSA) and Anti-Ds DNA tests on average, the chance of a positive test result increases by about 25% (P = 0.020 *, OR = 1.246, CI: 1.036-1.499) and increases by about 16% (P = 0.015 *, OR = 1.165, CI: 1.030-1.317) for both tests. There was no significant relationship between age of onset and other test results.Conclusion: The present study shows an increase in the age of onset of the disease and also a decrease in the percentage of renal disorders compared to the study of the previous two decades in Iran. Also, the significant relationship between Maral Rush and Oral Ulcer with Anti-Ds DNA’s affinity is a confirmation of the results of extensive studies on this’s affinity, which is also confirmed by the ACR criterion.