Systematic review. Protocol and registration
The systematic review was carried out by OACI and is registered in
PROSPERO (Ref. CRD42021224412). The review was designed following PRISMA
guidelines and the PECOS method: patients with LCS and lymph node
metastasis of thyroid papillary carcinoma (P= patient); histopathologic
analysis (E=exposure); non laryngeal location (C=comparator);
clinical-pathological aspects (O=outcome); case reports (S=type of
study). Eligibility criteria were studies describing cases of LCS
written in Spanish or English language. Exclusion criteria were letters
to the editor, meetings proceedings and articles with no abstract or
full text available (Figure 6).
We performed a comprehensive literature search using the PubMed, Web of
Science, Scopus and Embase databases for studies published until
December 2020.
The search included the terms “Larynx [MeSH terms] OR
Laryngeal [MeSH terms] OR Larynx [Title/Absctract] OR Laryngeal
[Title/Absctract] AND Chondrosarcoma [MeSH terms] OR
Chondrosarcoma [Title/Absctract]”. This process was supplemented
by hand searching in different peer-reviewed journals and databases.
Reference lists of retrieved articles were also checked.
The main objective of the research was to found all the cases of LCS
published to date. A secondary objective was to find the coexistence of
LCS with cervical LNMPTC in all the cases included in the search.