Systematic review. Protocol and registration
The systematic review was carried out by OACI and is registered in PROSPERO (Ref. CRD42021224412). The review was designed following PRISMA guidelines and the PECOS method: patients with LCS and lymph node metastasis of thyroid papillary carcinoma (P= patient); histopathologic analysis (E=exposure); non laryngeal location (C=comparator); clinical-pathological aspects (O=outcome); case reports (S=type of study). Eligibility criteria were studies describing cases of LCS written in Spanish or English language. Exclusion criteria were letters to the editor, meetings proceedings and articles with no abstract or full text available (Figure 6).
We performed a comprehensive literature search using the PubMed, Web of Science, Scopus and Embase databases for studies published until December 2020.
The search included the terms “Larynx [MeSH terms] OR Laryngeal [MeSH terms] OR Larynx [Title/Absctract] OR Laryngeal [Title/Absctract] AND Chondrosarcoma [MeSH terms] OR Chondrosarcoma [Title/Absctract]”. This process was supplemented by hand searching in different peer-reviewed journals and databases. Reference lists of retrieved articles were also checked.
The main objective of the research was to found all the cases of LCS published to date. A secondary objective was to find the coexistence of LCS with cervical LNMPTC in all the cases included in the search.