C26:0/C22:0 increase Compared to Wild Type C26:0/C22:0 increase Compared to Wild Type
Onset Age Blood Plasma/Serum Brain/Spinal cord Main site of neural damages
Human cALD <10 4~5-fold 3~14.5 fold Brain
Human AMN 20-30 Spinal cord/ Peripheral nerves
ABCD1- Mice 20-month 0~1-fold 4~5 fold Spinal Cord
Double KO Mice 12-month 3~4-fold 6~7-fold Spinal Cord