Experimental Groups and Protocol
Experimental Groups and Protocol were formed in three groups. Group 1 (Sham, n = 5): During the study, no procedure was performed except for anesthesia. Tissue and blood samples were taken at an hour corresponding to the end of the reperfusion period. Group 2 (Control, I / R, n = 5): After anesthesia, 60 minutes of ischemia and 60 minutes of reperfusion were applied to the infrarenal abdominal aorta, no medication was given. Tissue and blood samples were taken at an hour corresponding to the end of the reperfusion period. Group 3 (I / R + Curcumin, n = 5): 60 minutes of ischemia and 60 minutes of reperfusion were applied to the infrarenal abdominal aorta after anesthesia. 200 mg/kg Curcumin was administered intraperitoneally 5 minutes before the tourniquet was opened. (It has been shown that curcumin improves oxidative stress and inhibits the expression of inflammatory cytokines, and 200mg / kg as a dose is more effective 17. After comparing the curcumin doses used in ischemia reperfusion models, the curcumin dose was applied as 200mg/kg in our study). Tissue and blood samples were taken in the period corresponding to the end of the reperfusion period.