Statistical analysis
Minimum sample size required in each arm, calculated based on a previous study, were 33 subjects.16 Each outcome was defined as a febrile neutropenic event. All statistical analyses were performed using STATA version 16 (College Station, TX). Chi-square test (two-tailed) was used to compare proportion for categorical variables while t-test was used to compare means for continuous variables. Antibiotic utilization was reported as defined daily dose per 1000 patient-days. Trend of antibiotic utilization was analyzed by linear regression and reported as coefficient and p-value. Univariate and multivariate analysis of variables influencing on 30-day infectious diseases-related mortality were performed. All comparisons were 2-sided and a P value<0.05 was consider statistically significant.