5.1. Antigen prediction
The S, E, M and N are the main structural proteins of the coronavirus virions that the N proteins encompass a long RNA genome while the remnant immerge in lipid bilayer viral envelope. Based on previous experience with the SARS vaccine, it has been shown that only antibodies against various epitopes of the S protein neutralized the viral particles [36]. Therefore, the new SARS-CoV2 vaccines have focused at least on priming immune responses to some parts of the S protein especially S1 subunit and the RBD domain. However emerging non-neutralizing antibodies against all the structural and non-structural proteins and the subsequent disruptive ADE phenomenon saber rattling as the main obstacle in effective vaccination. So, considering the most constitutive as well as conserved viral proteins such as RNA polymerase [37] in vaccine design will provide a more confidential vaccine candidate and probably relieve us a lot of worries about possible future coronavirus infections as well.