3 RESULTS
A total of 569 singleton pregnancies were enrolled in our study, in which 39 cases were FGR, 57 were SGA and 473 were normal singleton pregnancies. The maternal clinical and neonates characteristics among the three groups are presented in Table 1. The maternal height in SGA group is shortest among the three groups. The maternal height in SGA group was significantly shorter than that in the AGA group (P < 0.001), however, no significant differences were observed AGA group and FGR group or between FGR group and SGA group (P ≥ 0.05). No significant differences in maternal age, gravida, parity and APO were observed among the three groups (P ≥ 0.05).
The parameters of UA velocities among the three groups are presented in Table 2. The UA velocities parameters were decreased with the severity of growth restriction. The UA-TAMXV and UA-PSV were reduced successively in AGA, SGA and FGR ( all P < 0.05). Multivariate logistic regression analysis suggested that the maternal height was predictive of SGA (P = 0.001) (Table 3). However, all of the UA velocities parameters were not independent predicting factors of SGA (P ≥ 0.05). The UA-TAMXV was an independent predicting factor of FGR (P = 0.029) (Table 4). However, there was no significant correlation between maternal height and FGR (P ≥ 0.05). As showed by the receiver operating characteristic (ROC) curves, the UA-TAMXV had moderate predictive value for FGR, with an area under the ROC curve of 0.821 [95% confidence interval (CI): 0.785-0.853], with sensitivity of 74.40% as well as specificity of 77.60%, respectively (Figure 1).