Analysis of sHLA-G dynamics across pregnancy
Loess regression approach: Loess (locally estimated scatter plot smoothing) curves were constructed to summarize and analyze the relationship between the period of gestation (in days) (treated as independent variable) and sHLA-G levels (treated as dependent variable) in SGA and AGA neonates. Due to the skewed distribution of the data, loess regression was applied using Generalized Additive Models for Location Scale and Shape “GAMLSS” package (available in R programming language).