Conclusion
The objective of this study was to determine the association between
circulatory levels of sHLA-G in pregnant mothers and SGA births. No
difference was observed in the trajectory of sHLA-G during the period of
pregnancy in mothers delivering SGA as compared to those delivering AGA.
However, a trend towards higher sHLA-G levels at first trimester was
observed in mothers delivering SGA, which can be explored further in
studies with a larger sample size. sHLA-G levels combined with clinical
and/or imaging (as seen in the ultrasound) risk factors could be used to
build predictive models for early prediction of SGA births. Early
prediction, proper management, and timely intervention of pregnancies
that could result in SGA, may help in decreasing the mortality and
morbidity in SGA neonates.