Electrochemical continuous-flow synthesis of spiro sulfonamide by oxidation dearomatization Ting Liu,†a Zhaojiang Shi,†a Yaofeng Yuan,a Yuqi Lin*,a and Ke-Yin Ye*,a Chin. J. Chem. 2023, 41, XXX—XXX. DOI: 10.1002/cjoc.202300XXX
An electrochemical dearomative spirocyclization of N-acyl sulfonamides in a continuous-flow cell was reported. This reaction is simple and effi-cient, and 10 g scale-up synthesis can be readily achieved without external catalysts or supporting electrolytes.