Abstract
Alzheimer’s disease (AD) is a neurological condition that is
significantly more prevalent when people become older. It may start out
early or late. A rise in levels of proinflammatory cytokines and
microglial activation, both of which contribute to the central nervous
system’s inflammatory state, are characteristics of AD (CNS). As opposed
to this, periodontitis is a widespread oral infection brought on by
gram-negative anaerobic bacteria. By releasing proinflammatory cytokines
into the systemic circulation, periodontitis can be classified as a
”low-grade systemic disease.” Periodontitis and AD are linked by
inflammation, which is recognized to play a crucial influence in both
the illness and treatment process.
The current review sought to highlight the effects of pro-inflammatory
cytokines, which are released during periodontal and Alzheimer’s
diseases in the pathophysiology of both conditions. It also addresses
the puzzling relationship between AD and periodontitis, highlighting the
etiology, and potential ramifications.