Figure legends
Figure 1. (A) Schematic view of this MR study for the
association between IMIDs and AA. IMIDs, Immune-mediated inflammatory
diseases, including inflammatory
bowel disease (IBD), Crohn’s disease (CD), ulcerative colitis (UC),
rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and
psoriasis (PSO). AA, aortic aneurysm. (B) Detailed flowchart of
the study design. IVs, instrumental variables.
Figures 2. Main result of estimates from MR analysis with
forward and reverse direction. (A)
(B), forward analysis. (C) (D), reverse analysis. IBD, inflammatory
bowel disease, CD, Crohn’s disease, UC, ulcerative colitis, RA,
rheumatoid arthritis, SLE, systemic lupus erythematosus, and PSO,
psoriasis. CI, confidence interval.
Supplementary Figure S1 Leave-one-out sensitivity
analysis. (A) IBD and AA, (B) CD and AA, (C) UC and AA, (D) RA and AA,
(E) SLE and AA, (F) PSO and AA, (G) AA and IBD, (H) AA and CD, (I) AA
and UC, (J) AA and RA, (K) AA and SLE, (L) AA and PSO.
Supplementary Figure S2 Funnel plot for IVW and MR-Egger
method. (A) IBD and AA, (B) CD and AA, (C) UC and AA, (D) RA and AA,
(E) SLE and AA, (F) PSO and AA, (G) AA and IBD, (H) AA and CD, (I) AA
and UC, (J) AA and RA, (K) AA and SLE, (L) AA and PSO.
Supplementary Figure S3 Scatter plot with all IVs. (A) IBD and
AA, (B) CD and AA, (C) UC and AA, (D) RA and AA, (E) SLE and AA, (F) PSO
and AA, (G) AA and IBD, (H) AA and CD, (I) AA and UC, (J) AA and RA, (K)
AA and SLE, (L) AA and PSO.