Figure legends
Figure 1. (A) Schematic view of this MR study for the association between IMIDs and AA. IMIDs, Immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD), Crohn’s disease (CD), ulcerative colitis (UC), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and psoriasis (PSO). AA, aortic aneurysm. (B) Detailed flowchart of the study design. IVs, instrumental variables.
Figures 2. Main result of estimates from MR analysis with forward and reverse direction. (A) (B), forward analysis. (C) (D), reverse analysis. IBD, inflammatory bowel disease, CD, Crohn’s disease, UC, ulcerative colitis, RA, rheumatoid arthritis, SLE, systemic lupus erythematosus, and PSO, psoriasis. CI, confidence interval.
Supplementary Figure S1 Leave-one-out sensitivity analysis. (A) IBD and AA, (B) CD and AA, (C) UC and AA, (D) RA and AA, (E) SLE and AA, (F) PSO and AA, (G) AA and IBD, (H) AA and CD, (I) AA and UC, (J) AA and RA, (K) AA and SLE, (L) AA and PSO.
Supplementary Figure S2 Funnel plot for IVW and MR-Egger method. (A) IBD and AA, (B) CD and AA, (C) UC and AA, (D) RA and AA, (E) SLE and AA, (F) PSO and AA, (G) AA and IBD, (H) AA and CD, (I) AA and UC, (J) AA and RA, (K) AA and SLE, (L) AA and PSO.
Supplementary Figure S3 Scatter plot with all IVs. (A) IBD and AA, (B) CD and AA, (C) UC and AA, (D) RA and AA, (E) SLE and AA, (F) PSO and AA, (G) AA and IBD, (H) AA and CD, (I) AA and UC, (J) AA and RA, (K) AA and SLE, (L) AA and PSO.