3 Results
3.1 Weight loss of mice was alleviative in MPO-/- mice under bacterial infection and hypoxia exposure.
After 2 days of the experiment, the weight of mice in the infection groups decreased significantly (Figure 1). On the 4th day, the weight of the mice in the NI group showed an upwards trend, and that of the mice in the KI group decreased significantly. Compared with the control group, the infection groups showed a significant change in the body weight of the mice, and the body weight decreased significantly (P<0.05), indicating that the infection caused the mice to lose weight; the HI group was compared with the NI and KI groups. Compared with that of mice in the HKI group, there was a difference in body weight change (P<0.05), and the weight loss of mice in the HI and HKI groups was more obvious, indicating that the hypoxic environment aggravated the weight loss of mice after infection. Comparing the MPO-/- and WT mice, the weight of the WT mice decreased significantly (P<0.05).