3.5 The effect of MPO in the chemotaxis of neutrophils and
macrophages of C. rodentium-infected mice under hypoxia
The results showed that compared with those of the control groups
(Figure 6 a-d), the expression levels of MIP2, KC and MCP1 in the spleen
and colon of each infected group were significantly increased
(P <0.05), while in hypoxia, the expression levels of
MIP2, KC and MCP1 in the spleen and colon were decreased compared with
those in the control condition (P <0.05), which
suggested that the neutrophil and macrophage chemotaxis capacity was
reduced in hypoxia. The results of fluorescence (Figure 7) quantitative
analysis showed that compared with that in the normal groups, the
expression of chemokines in the infected groups was significantly
increased, and the content of chemokines in the MPO-/-groups was even greater.