3 Results
3.1 Weight loss of mice was alleviative in
MPO-/- mice under bacterial infection
and hypoxia exposure.
After 2 days of the experiment, the weight of mice in the infection
groups decreased significantly (Figure 1). On the 4th day, the weight of
the mice in the NI group showed an upwards trend, and that of the mice
in the KI group decreased significantly. Compared with the control
group, the infection groups showed a significant change in the body
weight of the mice, and the body weight decreased significantly
(P<0.05), indicating that the infection caused the mice to
lose weight; the HI group was compared with the NI and KI groups.
Compared with that of mice in the HKI group, there was a difference in
body weight change (P<0.05), and the weight loss of mice in
the HI and HKI groups was more obvious, indicating that the hypoxic
environment aggravated the weight loss of mice after infection.
Comparing the MPO-/- and WT mice, the weight of the WT
mice decreased significantly (P<0.05).