Table 1. Comparison between Saracatinib, Nintedanib,
Pirfenidone |
Table 1. Comparison between Saracatinib,
Nintedanib, Pirfenidone |
Table 1. Comparison between
Saracatinib, Nintedanib, Pirfenidone |
Table 1. Comparison
between Saracatinib, Nintedanib, Pirfenidone |
Comparison aspect |
Saracatinib |
Ninetidanib |
Pirfenidone |
Mechanism of action |
Src kinase inhibitor. |
Tyrosine kinase
inhibitors. |
TGF-𝛃 and fibronectin inhibitor as well as p38 MAPK in B
lymphocytes. |
TGF- 𝛃 expression of profibrotic genes. |
Larger inhibitory effect
including ACTA2, COL1A1, and SERPIN1 |
Inhibits TGF- 𝛃 expression of
profibrotic genes. |
Inhibits TGF- 𝛃 expression of profibrotic
genes. |
TGF-β-induced Smad3 phosphorylation |
Inhibitory effect. |
No effect was
found. |
No effect was found. |
Experimental pulmonary fibrosis reduction |
Better effect. |
Less
effect. |
Less effect. |
Precision cuts lung slices results |
Better effect in reducing pulmonary
fibrosis. |
Less effect. |
Less effect. |