Figure 4. SRS 16-86 u-regulated system Xc-light chain (xCT), glutathione (GSH), and glutathione peroxidase 4 (GPX4) level and downregulated 4-hydroxynonenal (4HNE) level in diabetic nephropathy rats. The expression of xCT, GPX4, and GSH were increased while that of 4HNE was decreased after treatment with SRS 16-86 (n=6/group). (ns:P>0.05; *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001)