Figure 2. 24-hour urine volume, creatinine (CRE2U), and urine total protein (UTP) after streptozotocin treatment. 24-hour urine volume and the content of CRE2U and UTP in the DN and DN-SRS groups were markedly higher than those control group at the 8-week time point after STZ treatment, proving that the diabetic nephropathy animal model was successfully constructed (n=6/group). (ns:P>0.05; *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001)