Figure 1. Establishment of the diabetes mellitus and diabetic nephropathy (DN) animal models. (A) A diabetes mellitus (DM) animal model was established with a single intraperitoneal injection of freshly prepared streptozotocin (60 mg/kg); the DN-SRS group was treated with am intraperitoneal injection of SRS 16-86 with the dose of 15 mg/kg once/day from week 1 to 8 week after STZ treatment. (B, C) Blood glucose and body weight after STZ treatment (n=6).