3.1 Curcumin inhibits psoriasis-like skin lesions induced by
IMQ
To further clarify the regulatory effect of CUR on psoriasis, we
constructed psoriasis-like skin lesions induced by IMQ (Figure. 1A). As
shown in Figure.1B-D, PASI scores were largely increased in IMQ-induced
mice than in control mice. CUR could significantly decrease PASI scores
and epidermal thickness in affected lesions of IMQ-induced mice (Figure.
1B-E). Therefore, CUR could relieve the IMQ-induced mouse skin lesions
and reduce the PASI scores in the affected areas.