1.3.5 LncRNA and miRNA mutually repress each other
While lnc MIR31HG can act as a sponge to bind miR-193b, miR-193b can also directly target two binding sites on lnc MIR31HG, negatively regulates lnc MIR31HG levels, induces apoptosis and G1/S phase arrest, and reduces the cell growth of pancreatic ductal adenocarcinoma. These mutually inhibitory effects contribute to the growth of tumors[28]. A negative feedback pathway is formed between lnc MALAT1 and miR-200c-3p. On the one hand, miR-200c-3p can mediate the silencing of MALAT1, which plays a significant role in the migration and invasion of pancreatic ductal adenocarcinoma and can be used as a prognostic indicator. On the one hand, the high expression of lnc MALAT1 in pancreatic ductal adenocarcinoma inhibits the expression of miR-200c-3p[29].
See the details of the mechanism in Fig 1.