1.3.5 LncRNA and miRNA mutually repress each other
While lnc MIR31HG can act as a sponge to bind miR-193b, miR-193b can
also directly target two binding sites on lnc MIR31HG, negatively
regulates lnc MIR31HG levels, induces apoptosis and G1/S phase arrest,
and reduces the cell growth of pancreatic ductal adenocarcinoma. These
mutually inhibitory effects contribute to the growth of tumors[28].
A negative feedback pathway is formed between lnc MALAT1 and
miR-200c-3p. On the one hand, miR-200c-3p can mediate the silencing of
MALAT1, which plays a significant role in the migration and invasion of
pancreatic ductal adenocarcinoma and can be used as a prognostic
indicator. On the one hand, the high expression of lnc MALAT1 in
pancreatic ductal adenocarcinoma inhibits the expression of
miR-200c-3p[29].
See the details of the mechanism in Fig 1.