1.3.1 LncRNA represses miRNA expression
LncRNA bind with miRNA and suppress its expression by common binding
sites, or lncRNA directly suppressing miRNA precursors or primary
miRNAs, thereby lowering transcription product creation. Lnc-PFAR stems
pre-miR-141 maturation by binding with pre-miR-141 in 72 Nucleotide
binding domain, thus reducing miR-141 expression[15]. Rather than
direct bind and interact with mature miRNA, lnc uc.173 combined with
pri-miR-195 in its central stem region, destabilizing and enhancing
degradation of pri-miR-195, thus inhibiting Dorsha-mediated pri-miRNA
processing to pre-miRNA, and deregulate the expression of
miR-195[16]. In addition, the binding of lncRNA to miRNA, or miRNA
binding sponge, exerts a role in inhibiting miRNA function, while
further affect the mRNA levels of miRNA downstream targets, and this
mechanism of interaction by competitively binding miRNA to mRNA is known
as the ceRNA mechanism.