Autoimmune Disease miRNA Regulation Mechanism Reference
Rheumatoid Arthritis
miRNA-126-3p, let-7d-5p, miRNA-431-3p, miRNA-221-3p, miRNA-24-3p, miRNA-130a-3p, miRNA-339-5p, let-7i-5p, miRNA-486-5p
Upregulated
Promotes apoptosis and proinflammatory markers Anti-proliferative effect and increases the apoptotic death of FLSs Maintains homeostasis and associated with cartilage development pathways
miRNA-320a, miRNA-132, miRNA-363, miRNA-498a, miRNA-124a, miRNA-140, let-7a, miR-204-5p Downregulated
Diabetes
miRNA-375, miRNA-29a, miRNA-29b, miRNA-200, miRNA-7, miRNA-140-3p, miRNA-574-3p, miRNA-139-5p, miRNA-106a, miRNA-17, miRNA-486-3p, miRNA16, miRNA-222, miRNA-885-5p, miRNA-197
Upregulated
Malabsorption of glucose and insulin resistance Maintains glucose homeostasis Beta cell differentiation and proliferation, regulates apoptosis Controls glucose and lipid metabolism
miRNA-155, miRNA-92a, miRNA-126, miRNA-34a, miRNA-214-3p miRNA-27-3p Downregulated
Multiple Sclerosis
miRNA-155, miRNA-146a/b, miRNA-214, miRNA-23a, miRNA-219, miRNA-338, miRNA-128, miRNA-27b, miRNA-340, miRNA-29b, miRNA-326, miRNA-301a, miRNA-17-5p
Upregulated
miRNA expression altered in CNS lesions and in the immune system, which effects gene expression and promotes the disease Contribute towards Th-17 differentiation and polarization
miRNA-219, miRNA-338, miRNA-23b, miRNA-25, miRNA-15a, miRNA-16-1 miRNA-17-92 cluster Downregulated
Systemic Lupus Erythematosus
miRNA-155, miRNA-15a, miRNA-124-3p, miRNA-377-3p, miRNA-21, miRNA-7, miRNA-34a, miRNA-148a, miRNA-126,
Upregulated
Involved in Apoptotic pathway Triggers inflammation, exaggerated immunogenic response and pathogenesis
miRNA-17, miRNA-142-3p, miRNA-146a, miRNA-125b Downregulated
Inflammatory Bowel Disorder
miRNA-101, miRNA-515-5p, miRNA-623, miRNA-325, miRNA-876-5, miRNA-1224-5p, miRNA-1226-5p, miRNA-1253, miRNA-455, miRNA-20a, miRNA-17-5p, miRNA-424, miRNA-16-5p, miRNA-21-5p
Upregulated
Serve as biomarkers for disease diagnosis Enhances paracellular permeability of the intestinal epithelium Boosts zonulin expression and promotes epithelial permeability Reduces the expression of aquaporin 3, resulting in a weakening of the intestinal barrier
miRNA-24, miRNA-107, miRNA-10a, miRNA-223, miRNA-9, miRNA-21, miRNA-874, miRNA-150, miRNA-125b, miRNA-17-92, Downregulated