\documentclass[10pt]{article}

\usepackage{fullpage}
\usepackage{setspace}
\usepackage{parskip}
\usepackage{titlesec}
\usepackage[section]{placeins}
\usepackage{xcolor}
\usepackage{breakcites}
\usepackage{lineno}
\usepackage{hyphenat}





\PassOptionsToPackage{hyphens}{url}
\usepackage[colorlinks = true,
            linkcolor = blue,
            urlcolor  = blue,
            citecolor = blue,
            anchorcolor = blue]{hyperref}
\usepackage{etoolbox}
\makeatletter
\patchcmd\@combinedblfloats{\box\@outputbox}{\unvbox\@outputbox}{}{%
  \errmessage{\noexpand\@combinedblfloats could not be patched}%
}%
\makeatother


\usepackage{natbib}




\renewenvironment{abstract}
  {{\bfseries\noindent{\abstractname}\par\nobreak}\footnotesize}
  {\bigskip}

\titlespacing{\section}{0pt}{*3}{*1}
\titlespacing{\subsection}{0pt}{*2}{*0.5}
\titlespacing{\subsubsection}{0pt}{*1.5}{0pt}


\usepackage{authblk}


\usepackage{graphicx}
\usepackage[space]{grffile}
\usepackage{latexsym}
\usepackage{textcomp}
\usepackage{longtable}
\usepackage{tabulary}
\usepackage{booktabs,array,multirow}
\usepackage{amsfonts,amsmath,amssymb}
\providecommand\citet{\cite}
\providecommand\citep{\cite}
\providecommand\citealt{\cite}
% You can conditionalize code for latexml or normal latex using this.
\newif\iflatexml\latexmlfalse
\providecommand{\tightlist}{\setlength{\itemsep}{0pt}\setlength{\parskip}{0pt}}%

\AtBeginDocument{\DeclareGraphicsExtensions{.pdf,.PDF,.eps,.EPS,.png,.PNG,.tif,.TIF,.jpg,.JPG,.jpeg,.JPEG}}

\usepackage[utf8]{inputenc}
\usepackage[english]{babel}



\usepackage{float}








\begin{document}

\title{Complex Interplay Between Metabolism and CD4 + T cell Activation,
Differentiation and Function: A Novel Perspective for Atherosclerosis
Immunotherapy}



\author[1]{danyan xu}%
\author[1]{Jingmin Yang}%
\author[1]{Yanying Chen}%
\author[1]{Xiao Li}%
\author[1]{Huali Qin}%
\author[1]{Jinghui Bao}%
\author[1]{Chunfang Wang}%
\author[1]{Xiaochen Dong}%
\affil[1]{The Second Xiangya Hospital of Central South University}%


\vspace{-1em}



  
  \date{May 20, 2024}


\begingroup
\let\center\flushleft
\let\endcenter\endflushleft
\maketitle
\endgroup





\selectlanguage{english}
\begin{abstract}
Atherosclerosis is a complex pathological process that is based on the
chronic inflammatory reaction of the blood vessel wall and involves
various immune cells and cytokines. The imbalance in the proportion and
function of effector CD4 \textsuperscript{+} T cell (Teff) and
regulatory T cell (Treg) subsets is an important cause of the occurrence
and development of atherosclerotic plaques. Teff cells depend on
glycolytic metabolism and glutamine catabolic metabolism, while Treg
cells mainly rely on fatty acid oxidation (FAO) for energy, which is
crucial for determining the fate of CD4 \textsuperscript{+} T cell
differentiation and maintaining their respective immune functions. Here,
we review recent research achievements in the field of immunometabolism
related to CD4 \textsuperscript{+} T cell, focusing on the cellular
metabolic pathways and metabolic reprogramming involved in the
activation, proliferation and differentiation of CD4 \textsuperscript{+}
T cell. Subsequently, we discuss the important roles of mTOR and AMPK
signaling in regulating the fate of CD4 \textsuperscript{+} T cell
differentiation. Finally, we evaluate the links between CD4
\textsuperscript{+} T cell metabolism and atherosclerosis, highlighting
the potential of targeted modulation of CD4 \textsuperscript{+} T cell
metabolism in the prevention and treatment of atherosclerosis in the
future.%
\end{abstract}%



\sloppy


\textbf{Hosted file}

\verb`manuscript.docx`  available at \url{https://authorea.com/users/723629/articles/708135-complex-interplay-between-metabolism-and-cd4-t-cell-activation-differentiation-and-function-a-novel-perspective-for-atherosclerosis-immunotherapy}

\selectlanguage{english}
\FloatBarrier
\end{document}

