Introduction
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder
with variable disease courses and multiple clinical manifestations. The
etiology of SLE is not clear, but different environmental (ultraviolet
[UV] light, infections, drugs), genetic, and hormonal factors all
seem to be involved. Positive family history and history of having other
autoimmune illnesses are considered high-risk factors for SLE, but most
SLE cases are scattered. The 2019 EULAR/ACR classification criteria for
SLE include positive ANA at least once as a mandatory entry criterion;
followed by additive weighted standards grouped in seven clinical
(constitutional, hematological, neuropsychiatric, serosal,
musculoskeletal, renal, mucocutaneous ) and three immunological
(antiphospholipid antibodies, complement proteins, SLE-specific
antibodies) domains, and weighted from 2 to 10, and patients
accumulating ≥10 points are classified to have SLE. Herein, we report
this case of neuropsychiatric lupus as it is uncommon and is a severe
form of SLE.