List of abbreviations:
DOAC - direct oral anticoagulant; DVT – deep vein thrombosis; EV - extracellular vesicle; FXa -Factor Xa; MS - mass spectrometry; LC-MS/MS - liquid chromatography tandem mass spectrometry; LFQ - label-free quantification; PAR – protease activated receptor; PE- pulmonary embolism; VKA - vitamin K antagonist, VTE – venous thromboembolism