SD – standard deviation, BMI – body mass index, INR – international
normalised ratio, TTR – time in therapeutic range, TIA – transient
ischemic attack; continuous variables were assessed for statistical
difference using a student’s t -test, categorical variables were
assessed using a Fisher exact test, p -values < 0.05
were regarded statistically significant
Table 2: EV proteins
differentially expressed between baseline and 6 months follow-up. One
protein was uniquely attributed to the Rivaroxaban-treated patient
cohort. Statistical analysis using an unpaired Welch’s-test with a false
discovery rate of 5 % and a minimal fold change of 0.1 revealed
statistically significant increased expression of 5 proteins in EV
preparations from Rivaroxaban-treated patients relative to warfarin.
Mean label free quantification (LFQ) values for each cohort and the
difference of the means are displayed for each protein.