SD – standard deviation, BMI – body mass index, INR – international normalised ratio, TTR – time in therapeutic range, TIA – transient ischemic attack; continuous variables were assessed for statistical difference using a student’s t -test, categorical variables were assessed using a Fisher exact test, p -values < 0.05 were regarded statistically significant

Table 2: EV proteins differentially expressed between baseline and 6 months follow-up. One protein was uniquely attributed to the Rivaroxaban-treated patient cohort. Statistical analysis using an unpaired Welch’s-test with a false discovery rate of 5 % and a minimal fold change of 0.1 revealed statistically significant increased expression of 5 proteins in EV preparations from Rivaroxaban-treated patients relative to warfarin. Mean label free quantification (LFQ) values for each cohort and the difference of the means are displayed for each protein.