Abstract
We report a case with clinical presentations of newly onset
hypertension, edema, serositis, and nephrotic syndrome, and a kidney
biopsy showing diffuse proliferative glomerulonephritis with
”full-house” immune deposits and thrombotic microangiopathy (TMA).The
findings were suggestive of lupus nephritis(LN). However, despite
persistent hypocomplementemia, her serological tests for autoantibodies
associated with systemic lupus erythematosus, (including antinuclear
antibody, anti-double-stranded DNA antibody, lupus anticoagulant,
anticardiolipin antibody, and Coombs’ test) were all negative. Although
the patient did not meet the diagnostic criteria for LN based on the
2019 EULAR/ERA-EDTA lupus guideline, she was treated as such based on
her biopsy results and clinical suspicion. This case report presents a
challenging case of seronegative diffuse proliferative
glomerulonephritis with “full-house” immune deposits and TMA.