Abstract
We report a case with clinical presentations of newly onset hypertension, edema, serositis, and nephrotic syndrome, and a kidney biopsy showing diffuse proliferative glomerulonephritis with ”full-house” immune deposits and thrombotic microangiopathy (TMA).The findings were suggestive of lupus nephritis(LN). However, despite persistent hypocomplementemia, her serological tests for autoantibodies associated with systemic lupus erythematosus, (including antinuclear antibody, anti-double-stranded DNA antibody, lupus anticoagulant, anticardiolipin antibody, and Coombs’ test) were all negative. Although the patient did not meet the diagnostic criteria for LN based on the 2019 EULAR/ERA-EDTA lupus guideline, she was treated as such based on her biopsy results and clinical suspicion. This case report presents a challenging case of seronegative diffuse proliferative glomerulonephritis with “full-house” immune deposits and TMA.