Figure 5 . Neutralization assay against pseudotyped SARS-CoV-2 Omicron BA.5 and viral load reduction assay in immunized mouse sera on day 35 against authentic SARS-CoV-2 Omicron BA.5.2. Neutralization assay was conducted by vaccinated mouse sera on days 21 and 35 against pseudotyped SARS-CoV-2 Omicron BA.5. VeroE6-TMPRSS2 cells were used for authentic viral infection, and virus copies in the cell culture supernatants were quantified by real-time one-step qRT-PCR. (A) Neutralizing antibodies against SARS-CoV-2 Omicron BA.5 pseudovirus by mouse sera collected on day 21. (B) Neutralizing antibodies against SARS-CoV-2 Omicron BA.5 pseudovirus by mouse sera collected on day 35. (C) Viral load reduction assay on SARS-CoV-2 Omicron BA.5.2 by mouse sera collected on day 35. Error bars represent SD.