Additional LI Analysis
There was no meaningful LI drop observed after PEF ablation for any cohort (NTC: 3Ω, LTC: 1Ω, HTC: 2Ω; p>0.7 for all cohort combinations). After 30 days, under guidance of EAM and ICE, the LAF catheter was placed in three areas of varying bipolar electrogram voltage: High-Voltage Zone (≥1mV), Border Zone (0.1-0.9mV), and Scar Zone (<0.1mV). LI response was reduced in the border zone (∆12Ω, IQR: 10-14Ω) and scar zone (∆8Ω, IQR: 6-9Ω) compared to the high-voltage zone (∆29Ω, IQR: 28-33Ω) using similar levels of contact (Figure 6 ). Analysis of lesion depth by the number of splines with CTC>10Ω revealed PEF treatment size was largely not impacted by catheter orientation or the number of splines in contact as long as stable CTC was achieved (Figure 7).