Limitations:
This study was conducted in healthy swine and results may vary in humans or in scarred or diseased tissue. Lesion assessment was done on fresh TTC-stained tissue and all images were retrospectively analyzed for lesion dimensions using methods that are well established preclinically but impossible to validate clinically. Steps were taken to ensure measurement systems were calibrated correctly and TTC procedures were identical in all animals. All findings in this study use a proprietary biphasic waveform and investigational catheter design that may not be generally applicable for predicting treatment results of different PEF waveforms, systems, and catheters.