|
Difference cold stimulus – rest |
Difference cold
stimulus – rest |
|
Day -1 |
Day 10 |
Systolic Blood Pressure (mmHg) |
Systolic Blood Pressure (mmHg) |
Systolic Blood Pressure (mmHg) |
Zamicastat
|
30±11
|
32±11
|
Placebo
|
29±10
|
36±9
|
Diastolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Zamicastat
|
19±6
|
21±7
|
Placebo
|
19±8
|
22±8
|
Heart Rate (bpm) |
Heart Rate (bpm) |
Heart Rate (bpm) |
Zamicastat
|
8±6
|
9±7
|
Placebo
|
10±6
|
11±6
|
CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate;
n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP:
systolic blood pressure; SD: standard deviation |
CPT: cold pressure
test; DPP: diastolic blood pressure; HR: heart rate; n: number of
subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood
pressure; SD: standard deviation |
CPT: cold pressure test; DPP:
diastolic blood pressure; HR: heart rate; n: number of subjects; PP-PD:
per-protocol pharmacodynamics; SBP: systolic blood pressure; SD:
standard deviation |