Estimate* One-Sided 95% CI p-value
SBP (mmHg) -4.62 -7.77 0.020
DBP (mmHg) -1.86 -3.55 0.073
HR (bpm) 0.81 -0.66 0.354
*Estimates correspond to the difference between zamicastat and placebo for cold stimulus – rest phases on the change from baseline; treatment was used as fixed effect. DBP, Diastolic Blood Pressure; HR, Heart Rate; PP-PD: per-protocol pharmacodynamics; SBP, Systolic Blood Pressure. *Estimates correspond to the difference between zamicastat and placebo for cold stimulus – rest phases on the change from baseline; treatment was used as fixed effect. DBP, Diastolic Blood Pressure; HR, Heart Rate; PP-PD: per-protocol pharmacodynamics; SBP, Systolic Blood Pressure. *Estimates correspond to the difference between zamicastat and placebo for cold stimulus – rest phases on the change from baseline; treatment was used as fixed effect. DBP, Diastolic Blood Pressure; HR, Heart Rate; PP-PD: per-protocol pharmacodynamics; SBP, Systolic Blood Pressure. *Estimates correspond to the difference between zamicastat and placebo for cold stimulus – rest phases on the change from baseline; treatment was used as fixed effect. DBP, Diastolic Blood Pressure; HR, Heart Rate; PP-PD: per-protocol pharmacodynamics; SBP, Systolic Blood Pressure.