HR: 𝐻0:𝜇𝑍−𝜇𝑃≥−4.1,
where 𝜇𝑍 and 𝜇𝑃 represent the mean of each endpoint for zamicastat and placebo, respectively.
Missing data were not replaced, and no imputation was conducted; descriptive statistics and statistical analysis were performed based on the available data only.