Pharmacokinetic results
Geometric mean trough plasma concentration versus time profiles of zamicastat, following administration of zamicastat 400 mg once daily for 10 days, are displayed in Figure 2 , in linear scale (n=21). From visual inspection, steady-state plasma concentrations of zamicastat and its metabolites appeared to be reached at day 6 approximately. The geometric mean of zamicastat concentration ranged from 45.86±1.46 ng/mL on day 3 to 58.64±1.52 ng/mL on day 10. The inter-individual variability was moderate, with coefficients of variation ranging from 32.6% to 36.6% during the 10 days of zamicastat 400 mg once daily administration.