|
Day -1 |
Day -1 |
Day -1 |
Day 10 |
Day 10 |
Day 10 |
|
Rest |
Cold Stimulus |
Recovery |
Rest |
Cold Stimulus |
Recovery |
Systolic Blood Pressure (mmHg) |
Systolic Blood Pressure (mmHg) |
Systolic Blood Pressure (mmHg) |
Systolic Blood Pressure (mmHg) |
Systolic Blood Pressure (mmHg) |
Systolic Blood Pressure (mmHg) |
Systolic Blood Pressure (mmHg) |
Zamicastat
|
119±9
|
149±15
|
125±10
|
124±11
|
156±15
|
130±11
|
Placebo
|
121±13
|
150±18
|
128±14
|
122±14
|
158±19
|
131±13
|
Diastolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Diastolic Blood Pressure (mmHg) |
Zamicastat
|
59±6
|
78±10
|
63±7
|
61±4
|
82±10
|
65±7
|
Placebo
|
59±8
|
78±13
|
63±8
|
60±5
|
82±11
|
65±7
|
Heart Rate (bpm) |
Heart Rate (bpm) |
Heart Rate (bpm) |
Heart Rate (bpm) |
Heart Rate (bpm) |
Heart Rate (bpm) |
Heart Rate (bpm) |
Zamicastat
|
63±8
|
70±9
|
59±6
|
63±9
|
73±8
|
60±9
|
Placebo
|
62±7
|
71±9
|
59±6
|
62±6
|
72±9
|
59±6
|
CPT: cold pressure test; DPP: diastolic blood pressure; HR: heart rate;
n: number of subjects; PP-PD: per-protocol pharmacodynamics; SBP:
systolic blood pressure. |
CPT: cold pressure test; DPP: diastolic blood
pressure; HR: heart rate; n: number of subjects; PP-PD: per-protocol
pharmacodynamics; SBP: systolic blood pressure. |
CPT: cold pressure
test; DPP: diastolic blood pressure; HR: heart rate; n: number of
subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood
pressure. |
CPT: cold pressure test; DPP: diastolic blood pressure; HR:
heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics;
SBP: systolic blood pressure. |
CPT: cold pressure test; DPP: diastolic
blood pressure; HR: heart rate; n: number of subjects; PP-PD:
per-protocol pharmacodynamics; SBP: systolic blood pressure. |
CPT: cold
pressure test; DPP: diastolic blood pressure; HR: heart rate; n: number
of subjects; PP-PD: per-protocol pharmacodynamics; SBP: systolic blood
pressure. |
CPT: cold pressure test; DPP: diastolic blood pressure; HR:
heart rate; n: number of subjects; PP-PD: per-protocol pharmacodynamics;
SBP: systolic blood pressure. |