3.2 NSC-Exos can improve the cognitive learning ability of MCAO
model rats and has neuroprotective effect
To test whether NSC-Exos improves cognitive function in rats, we tested
their spatial learning and memory abilities using a Morris water maze.
Compared with Sham group, IRI group and PBS group, the escape latency
was prolonged, the swimming distance and the time required to explore
the target quadrant were increased (P< 0.01), and the
movement track was disorganized. Compared with IRI group and PBS group,
the escape latency, swimming distance and exploration target quadrant
time of NSC-Exos group were shortened (P< 0.01, Fig.
2a,b,c), and the direction of motion trajectory was more clear (Fig.
2d).