Statistics
Statistical analysis was performed by using R (version 4.2.2) with packages ggsurvfit, ggthemes, tidycmprsk, tidyverse22. Categorical variables were compared using Fischer’s exact test and continuous variables using the Mann-Whitney U-test. A p-value <0.05 was considered significant. Time to reach maintenance in subgroups was compared using the cumulative incidence function and Gray’s test. Reaching maintenance was considered to be the event of interest, stopping therapy a competing event and the patients still continuing therapy were right censored on their last clinical follow-up.