Comparison of the distribution and mortality of drug-resistant
bacteria among AYAs, children, and adults
After following detailed inclusion and exclusion criteria, 215 bacterial
cases (59.2%) caused by MDR strains in ALL patients were enrolled in
the study. Several common MDR bacteria in the three groups are
summarized in this article (Fig. 3A). The ESBL-producing strains were
the most common organisms found on MDR strains in the AYAs and adult
groups (32.8% vs. 24.6%), whereas methicillin-resistant staphylococcus
(MRS) strains occupied a quality position (17.8%) in the pediatric
population, which was significantly higher than those in the AYAs and
adult groups (17.8% vs. 2.2%, P<0.001; 17.8% vs. 3.6%,
P=0.001). There was no difference in the detection of
carbapenem-resistant organisms (CRO) in AYAs compared with the other two
groups, and the rates in children, AYAs, and adults were 6.8%, 5.6%,
and 4.6%, respectively. Meanwhile, we also compared the mortality of
drug-resistant bacteria in three groups (Fig.3B), the mortality rate
caused by ESBL-producing strains among three groups were lowest giving
an incidence of children, AYAS and adults groups of 16.7%, 18.6% and
22.2% respectively. Meanwhile, 8 ALL patients died from CRO, including
1 (20%) child, 5 (50%) AYAS, and 2 (40%) adult patients. Notably,
although the highest detection rate of MRS was observed in children with
ALL, none of them died.