Comparison of the distribution and mortality of drug-resistant bacteria among AYAs, children, and adults
After following detailed inclusion and exclusion criteria, 215 bacterial cases (59.2%) caused by MDR strains in ALL patients were enrolled in the study. Several common MDR bacteria in the three groups are summarized in this article (Fig. 3A). The ESBL-producing strains were the most common organisms found on MDR strains in the AYAs and adult groups (32.8% vs. 24.6%), whereas methicillin-resistant staphylococcus (MRS) strains occupied a quality position (17.8%) in the pediatric population, which was significantly higher than those in the AYAs and adult groups (17.8% vs. 2.2%, P<0.001; 17.8% vs. 3.6%, P=0.001). There was no difference in the detection of carbapenem-resistant organisms (CRO) in AYAs compared with the other two groups, and the rates in children, AYAs, and adults were 6.8%, 5.6%, and 4.6%, respectively. Meanwhile, we also compared the mortality of drug-resistant bacteria in three groups (Fig.3B), the mortality rate caused by ESBL-producing strains among three groups were lowest giving an incidence of children, AYAS and adults groups of 16.7%, 18.6% and 22.2% respectively. Meanwhile, 8 ALL patients died from CRO, including 1 (20%) child, 5 (50%) AYAS, and 2 (40%) adult patients. Notably, although the highest detection rate of MRS was observed in children with ALL, none of them died.