Patient Demographics
Three hundred forty patients with IH were included and evaluated in this
study. Baseline patient demographic data and lesion data can be seen in
Table 1, respectively. There were 230 (67.6%) female and 110 (32.4%)
male patients, with a mean weight of 6.8 kg at the time of propranolol
initiation.
The majority of patients identified as Caucasian (94%), with 11
patients identifying as Black or African American and 7 as Asian.
Approximately 93% of patients were non-Hispanic, while a smaller
percentage (6%) were Hispanic. Of the 340 patients included, 77 (23%)
were born prematurely, of which 27 (35%) were born <32 weeks,
and 49 (64%) were born between 32 and 37 weeks. Thirty-three patients
had a diagnosis of an associated syndrome, which was PHACES (Posterior
fossa anomalies, Hemangioma, Arterial lesions, Cardiac abnormalities,
and Eye anomalies). Lesions of the head/face had a statistically
significant association with a diagnosis of PHACE syndrome
(p<0.001). Forty-eight (14%) patients had a positive family
history of cardiac abnormalities (Wolf Parkinson White Syndrome, MI
<40 years old, congenital heart defect, death due to
congenital heart defect) or hemangiomas.