Results
Three hundred forty patients with IH were included in this study, with a
prevalence of focal lesions (71%) and a total of 279 (82%) IH located
on the head/neck. Lesions of the head had a statistically significant
association with PHACE syndrome (p<0.001). Most patients
initiated propanolol treatment before the age of 6 months (71%), with
continuation for ≥6 months (69%). Upon discontinuation of propranolol,
14 (4%) patients required a second cycle of propranolol for regrowth.
After controlling for IH location, patients with a family history of
hemangiomas or cardiac abnormalities were 3.6 times more likely to need
a second round of propranolol treatment (OR, 3.6; 95% Confidence
Interval 1.14-11.19) (P=0.03).