Figure 6. CDDO-Me suppresses macrophage infiltration in the liver of NASH mice
(a) Heatmap showing the expression of marker genes in macrophages, neutrophils, T cells, and B cells in the liver. (b) Hepatic sections stained with anti-F4/80 or anti-LY6G antibodies. Scale bars represent 100 μm in the upper panels and 20 μm in the lower panels. (c and d) F4/80 (c) or LY6G (d) positive cells counted in Figure. 6b (mean + S.D., n = 8). Statistical differences were analysed using Dunnett’s multiple comparison test (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 versus vehicle-treated CDAHFD-fed mice). Cont, Control; Veh, Vehicle. ns; not significant.