Bardoxolone methyl improves non-alcoholic steatohepatitis through inhibition of macrophage infiltration
Kazuhiro Onuma1,2, Kenji Watanabe1, Keishiro Isayama1, Sayaka Ogi2, Yasunori Tokunaga2, Yoichi Mizukami1*
1 Institute of Gene Research, Yamaguchi University Science Research Center, Yamaguchi, Japan,
2 Pharmaceutical Research Laboratory, Pharmaceutical Division, UBE Corporation, Yamaguchi, Japan
*Address Correspondence to : Yoichi Mizukami
Institute of Gene Research, Yamaguchi University Science Research Center, 1-1-1, Minami-kogushi, Ube, Yamaguchi, Japan 755-8505
Tel: +81-836-22-2183 /Fax: +81-836-22-2185
E-mail: mizukami@yamaguchi-u.ac.jp
Data availability statement : All data are presented in the manuscript or supplementary information.
The raw RNA-sequencing data are submitted to GEO under accession number GSE239861. Any further data will be made available to the corresponding author upon reasonable request.
Funding statement : This work was the result of using research equipment shared in MEXT Project for promoting public utilization of advanced research infrastructure (Program for supporting construction of core facilities) Grant Number JPMXS0440400021-23 and grants-in-aid for scientific research (Grant Nos. 21H03358 and 22K19711) from of the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Author contribution statement : KO designed the study, conducted the experiments, and wrote the manuscript. SO conducted the experiments. KW and KI supported the gene analysis and YT designed the study. YM designed the study and wrote the manuscript. All authors discussed the results and provided input to the manuscript.
Conflict of interest disclosure : The authors declare no conflicts of interest associated with this manuscript.
Ethics approval statement : All human and animal studies were approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments.