Bardoxolone methyl improves non-alcoholic steatohepatitis
through inhibition of macrophage infiltration
Kazuhiro Onuma1,2, Kenji Watanabe1,
Keishiro Isayama1, Sayaka Ogi2,
Yasunori Tokunaga2, Yoichi
Mizukami1*
1 Institute of Gene Research, Yamaguchi University
Science Research Center, Yamaguchi, Japan,
2 Pharmaceutical Research Laboratory, Pharmaceutical
Division, UBE Corporation, Yamaguchi, Japan
*Address Correspondence to : Yoichi Mizukami
Institute of Gene Research, Yamaguchi University Science Research
Center, 1-1-1, Minami-kogushi,
Ube, Yamaguchi, Japan 755-8505
Tel: +81-836-22-2183 /Fax: +81-836-22-2185
E-mail: mizukami@yamaguchi-u.ac.jp
Data availability statement : All data are presented in the
manuscript or supplementary information.
The raw RNA-sequencing data are submitted to GEO under accession number
GSE239861. Any further data will be made available to the corresponding
author upon reasonable request.
Funding statement : This work was the result of using research
equipment shared in MEXT Project for promoting public utilization of
advanced research infrastructure (Program for supporting construction of
core facilities) Grant Number JPMXS0440400021-23 and grants-in-aid for
scientific research (Grant Nos. 21H03358 and 22K19711) from of the
Ministry of Education, Culture, Sports, Science and Technology of Japan.
Author contribution statement : KO designed the study, conducted
the experiments, and wrote the manuscript. SO conducted the experiments.
KW and KI supported the gene analysis and YT designed the study. YM
designed the study and wrote the manuscript. All authors discussed the
results and provided input to the manuscript.
Conflict of interest disclosure : The authors declare no
conflicts of interest associated with this manuscript.
Ethics approval statement : All human and animal studies were
approved by the appropriate ethics committee and have therefore been
performed in accordance with the ethical standards of the 1964
Declaration of Helsinki and its later amendments.