Background
Scleroderma(SSc) is a rare connective tissue disorder of unknown
etiology characterized by thickness of the skin. The disease usually
affects patients between the ages of 30–50 (1). Scleroderma is
reported to be associated with Sjogren syndrome, rheumatoid arthritis
and systemic lupus erythematosus. It is also associated with solid
tumors such as lung, breast, stomach and rectum .however, the
association with multiple myeloma (MM) has seldomly been reported (2).
To the best of our knowledge, only 14 cases of sceleroderma associated
with MM have been reported in the literature. Inflammation and
deregulation of immune system in this autoimmune disorder may cause
clonal expansions of plasma cells but such aberrations still remain
under investigation(2,3).
We report a case of a 58-year-old woman who presented with Systemic
sclerosis associated with multiple myeloma.