Consent statement:Written informed consent was obtained from
the patient’s parents to publish this report in accordance with the
journal’s patient consent policy
Abstract: Primary mediastinum immature teratoma with
somatic-type malignant transformation (SM) is extremely rare, and the
clinical prognosis is poor. Immature teratoma with SM is hardly to be
eradicated by chemotherapy for the poor sensitivity, therefore surgical
resection is recommended whenever possible for it may offer a better
survival. We herein report a case of a chemotherapy-resistant and
extremely giant immature teratoma who received en bloc resection with
pathologic findings of foci of sarcoma and poorly differentiated
squamous cell carcinoma, and the literature is reviewed. To our best
knowledge, this is the largest primary mediastinum immature teratoma
with somatic-type malignant transformation treated with an en bloc
resection so far.
Key words: Primary mediastinum immature teratoma, somatic-type
malignant transformation, en bloc, surgery