ICD-10- International Classification of Diseases-10
*Estimation of functional improvement or decline is based on a comparison of the current overall functioning of the individual (physical, social, emotional, and cognitive realms) with the time before the initiation of LTOT. Hence, such functional estimations are subjective assessments based on narrative longitudinal history obtained from the patient in clinical practice. The improvement of pain and function transiently following each dose or with reinitiation of opioids after worsening pain following opioid tapering cannot be used as evidence of functional improvement.————End Box—————–