FIGURE 2 Yinxieling(YXL) dosen’t have significiant effect on dendritic cells in skin draining lymph nodes. A: Gating strategy and flow cytometry scatter plot to identify total dendritic cells and subsets; B: Frequency of total MHCII+DCs, B220+ plasmacytoid DCs, CD103-CD207+ LC, CD207+ and CD207- dermal DC subsets. n = 3, repreated at least twice with similar results. Comparing to IMQ group, *p <0.05, **p <0.01.
MHCII+CD207+ LCs in epidermis were detected by flow cytometry. The results showed that YXL significantly reduced the proportion and amount of LCs in the epidermis of psoriatic mice (p <0.001), as shown in FIGURE.3. It can reduce the inflammation of mouse skin induced by imiquimod and achieve the effect of treating psoriasis.