FIGURE 2 Yinxieling(YXL)
dosen’t have significiant effect on dendritic cells in skin draining
lymph nodes. A: Gating strategy and flow cytometry scatter plot to
identify total dendritic cells and subsets; B: Frequency of total
MHCII+DCs, B220+ plasmacytoid DCs,
CD103-CD207+ LC,
CD207+ and CD207- dermal DC subsets.
n = 3, repreated at least twice with similar results. Comparing to IMQ
group, *p <0.05, **p <0.01.
MHCII+CD207+ LCs in epidermis were
detected by flow cytometry. The results showed that YXL significantly
reduced the proportion and amount of LCs in the epidermis of psoriatic
mice (p <0.001), as shown in FIGURE.3. It can reduce the
inflammation of mouse skin induced by imiquimod and achieve the effect
of treating psoriasis.