3.1 Yinxieling(YXL) significantly alleviated Imiquimod induced psoriatic skin inflammation in mice.
After 7 days of continuous administration, the low dose (0.5 g/kg), medium dose (1.0 g/kg) and high (2.0 g/kg) dose of YXL extraction could significantly relieve the skin thickening, redness, scaling, inflammatory cell infiltration and other skin inflammation similar to psoriasis caused by imiquimot in mice, FIGURE.1A. Scores of YXL medium and high dose was significantly lower than that of IMQ group, FIGURE.1B. Further pathological analysis showed that the medium- and high-dose groups reduced the munro’s microcysts, cuticle laxity and abscission, epidermal hyperplasia, interspinous cell edema, spinous process prolongation and immune cell exudation caused by skin inflammation similar to psoriatic skin inflammation, FIGURE.1C