3.3 Yinxieling(YXL) inhibited the IMQ-induced migration of
epidermal langerhans cells (LCs)
Langerhans cell migration from the epidermis to the lymph nodes is
necessary for specific T lymphocyte responses. In a mouse model of
psoriasis-like skin inflammation induced by IMQ, it promoted the
migration of epidermal LC to dermal draining lymph nodes. In order to
clarify the role of YXL in regulating LC, the migration of LC was
studied. Fluorescein isothiocyanate (FITC) was dissolved in acetone and
applied to the back skin of mice. After 24 hours, the skin draining
lymph nodes were taken for flow cytometry detection. The results showed
that the ratio of FITC+LC was significantly reduced in
YXL treated group (p <0.001), indicating that YXL could
significantly inhibit the migration of IMQ-induced LC from the epidermis
to skin draining lymph nodes, FIGURE 4.