FIGURE 1 YinXieling(YXL) alleviates Imiquimod(IMQ)induced psoriasis-like murine dermatitis. A. Appearance sympotoms of mouse dermatitis; B. The modified psoriasis area and severity index (PASI) scores of the mouse back skin lesions; C. HE staining for murine skin lesions. IMQ: 0.5% Imiquimod cream, 50mg/day/mouse; CSA: cyclosporin A, 25 mg/kg; YXL-L: 0.5g/kg Yingxieling, YXL-M: 1g/kg Yingxieling, YXL-H: 2 g/kg Yingxieling. Data are shown as mean ± SD, n=6, *p < 0.05, **p < 0.01, comparing to IMQ group.
3.2 Yinxieling(YXL) had no significant effect on dendritic cell subsets in lymph nodes, but inhibited the ratio and number of epidermal langerhans cells (LCs)
The mice were intragastric with Yin Xieling liquid for 7 days, and skin draining lymph nodes were collected for flow analysis. The results showed that the proportion of dendritic cells (DCs) in skin draining lymph nodes of psoriatic mice were not significantly decreased. As well as there were no significant changes in B220+ plasmoid dendritic cells, CD103-CD207+Langerhans cells, CD207+ and CD207-dermal DCs subsets, as showed in FIGURE 2