Specific alterations of resting-state functional connectivity in the triple network related to comorbid anxiety in major depressive disorder
Fienne-Elisa Beckmann, BSc1* , fienne-elisa.beckmann@st.ovgu.deHanna Gruber1* , hanna.gruber@ovgu.deStephanie Seidenbecher, MSc1 , stephanie.seidenbecher@med.ovgu.deSaskia Thérèse Schirmer, MD1 , s.t.schirmer@tagesklinik-dr-kielstein.deCoraline D. Metzger, MD1 , coraline.metzger@med.ovgu.deLeonardo Tozzi, PhD3 , ltozzi@stanford.eduThomas Frodl, MD, PhD1,2,3,4 , tfrodl@ukaachen.de
1 Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Germany, 2 Department of Psychiatry, Trinity College Dublin, Ireland, 3Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, USA, 4 Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital RWTH Aachen, Germany
*These two authors contributed equally to this work.
Correspondence:Fienne-Elisa Beckmann, Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany E-mail: fienne-elisa.beckmann@st.ovgu.de Tel.: +49 176 75521202
The study was conducted in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki). Ethical approval for the study was granted by the Ethics Committee of the Otto-von-Guericke University. All participants received detailed oral and written information about the study and gave written informed consent prior to participation. All authors declare that they have no conflicts of interest. The study was funded through own funding from the department. Primary data can be provided in anonymised form after approval of the Ethics Committee of the Otto-von-Guericke University.
Keywords: Anxiety, Depression, Triple Network, Resting-state functional connectivity, Comorbidity
Word Count: 239 (Abstract), 3.518 (Text), 3 Tables, 1 Figure